Vertex Pharmaceuticals Incorporated (VRTX) Discusses Updated Data for Pove in IgAN and pMN and Developments in Kidney Disease Portfolio – Slideshow

**Vertex Pharmaceuticals Incorporated (VRTX) Q3 2025 Earnings Summary**

Vertex Pharmaceuticals Incorporated recently reported its Q3 2025 earnings, showcasing strong financial performance. The company reported an earnings per share (EPS) of $4.80, surpassing analysts’ expectations by $0.22. Revenue for the quarter reached $3.08 billion, representing a 10.99% year-over-year increase and beating estimates by $17.21 million.

In conjunction with this announcement, Vertex Pharmaceuticals published a detailed slide deck to provide further insights into the company’s performance and future outlook.

This article was prepared by Seeking Alpha’s Transcripts team, which is responsible for creating and managing all transcript-related content on our platform. Currently, we publish thousands of quarterly earnings calls each quarter and are continuously expanding our coverage to keep readers informed with the latest corporate developments.

Thank you for reading.
— The SA Transcripts Team

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https://seekingalpha.com/article/4840989-vertex-pharmaceuticals-incorporated-vrtx-discusses-updated-data-for-pove-in-igan-and-pmn-and?source=feed_all_articles

Xenon Pharmaceuticals Inc. (XENE) Q3 2025 Earnings Call Transcript

Operator: Good day, everyone, and thank you for standing by. My name is RJ, and I will be your conference operator today. At this time, I would like to welcome everyone to the Q3 2025 Xenon Pharmaceuticals, Inc. Earnings Conference Call.

[Operator Instructions]

I would now like to turn the call over to Colleen, Senior— or Xenon Senior Vice President of Corporate Affairs. Please go ahead.

**Colleen Alabiso:**
Good afternoon. Thank you for joining us on our call and webcast to discuss Xenon’s third quarter 2025 financial and operating results.

Joining me today are Ian Mortimer, President and Chief Executive Officer; Dr. Chris Kenney, Chief Medical Officer; Darren Cline, Chief Commercial Officer; and Tucker Kelly, our Chief Financial Officer.

After completing our prepared remarks today, we will open the call up for questions.

Please be advised that during this call, we will make a number of forward-looking statements. These include statements regarding the timing of and potential results from clinical trials, the potential efficacy and safety profile of our products, future development plans, current and anticipated indications, addressable markets, regulatory success, and the commercial potential of our and our partners’ product candidates.

We will also discuss the efficacy of our clinical trial designs and our ability to successfully develop and…
https://seekingalpha.com/article/4837165-xenon-pharmaceuticals-inc-xene-q3-2025-earnings-call-transcript?source=feed_all_articles

Vertex Pharmaceuticals Incorporated 2025 Q3 – Results – Earnings Call Presentation

**Vertex Pharmaceuticals Incorporated 2025 Q3 Results Earnings Call Presentation**
*November 3, 2025 | 11:08 PM ET*

**Vertex Pharmaceuticals Incorporated (VRTX) Stock**
*VRTX SA Transcripts | 156.39K Followers*

The following slide deck was published by Vertex Pharmaceuticals Incorporated in conjunction with their 2025 Q3 earnings call.

This article was prepared by Seeking Alpha’s transcripts team, who are responsible for the development of all our transcript-related projects. Currently, we publish thousands of quarterly earnings calls each quarter on our site and continue to grow and expand our coverage.

The purpose of this profile is to share with our readers new transcript-related developments.

Thank you,
SA Transcripts Team

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https://seekingalpha.com/article/4837196-vertex-pharmaceuticals-incorporated-2025-q3-results-earnings-call-presentation?source=feed_all_articles

Big Short Investor Michael Burry Breaks Silence to Warn of Market Bubble

**Michael Burry Issues First Market Warning Since April 2023, Cautions of Possible Bubble but Stays on Sidelines**

Michael Burry, the investor renowned for predicting the 2008 housing crisis, has made his first public statement since April 2023. On October 31, 2025, Burry posted a cryptic warning on X about a potential market “bubble,” while indicating he sees no clear way to profit from it.

His post read:
“Sometimes, we see bubbles. Sometimes, there is something to do about it. Sometimes, the only winning move is not to play.”
This quote references the 1983 movie *Wargames*, suggesting Burry recognizes risky speculation in the market but is choosing not to bet against it.

### “Cassandra Unchained” – A New Moniker with a Message

Burry also changed his X profile name to **“Cassandra Unchained.”** This nods to the Greek mythological figure Cassandra, who was cursed to make accurate predictions that nobody believed. The choice reflects Burry’s reputation for making accurate yet initially dismissed warnings.

### The Legacy of Michael Burry

Burry gained fame by predicting the collapse of the U.S. housing market before the 2008 financial crisis. He thoroughly analyzed subprime mortgages and used credit default swaps to short the housing sector. His foresight earned billions for his investors and was immortalized in the book and film *The Big Short*.

### What Bubble is Burry Warning About?

Unlike his previous clear identification of the housing bubble, Burry has not specified which market sector he is concerned about this time. Market observers speculate he may be referring to the technology sector, particularly the rapid rise of artificial intelligence (AI) investments.

Companies have invested hundreds of billions of dollars into AI infrastructure and data centers. For example, Nvidia’s market capitalization surpassed an astonishing $5 trillion as of October 29, 2025—exceeding the GDP of major economies like India, Japan, and Germany. This surge is largely driven by soaring demand for AI chips.

### Burry’s Current Market Position: Staying on the Sidelines

Unlike his famous housing market short, Burry is not betting against the market now. Instead, he appears to be taking a defensive, “wait and see” approach.

Throughout 2025, Burry’s Scion Asset Management has shown a shifting strategy:
– In Q1 2025, the firm liquidated nearly all its holdings, ending March with just seven positions. These included bets against Alibaba, JD.com, and Nvidia, plus shares in Estée Lauder.
– By the end of June, the portfolio expanded to 15 positions with call options on companies like Alibaba, Meta, ASML, UnitedHealth, Regeneron Pharmaceuticals, and Lululemon. Estée Lauder remained the only consistent holding throughout the year.

Burry’s upcoming 13-F filing, due in about two weeks, will reveal his holdings through the end of September 2025. His recent message suggests he may continue to adopt a cautious stance moving forward.

### Market Performance and AI Concerns

U.S. stock markets have performed strongly in 2025:
– The S&P 500 gained nearly 16% year-to-date.
– The Dow Jones Industrial Average rose 11.7%.
– The Nasdaq 100 surged 24.3%.

Tech companies have seen varied third-quarter earnings reactions. Meta and Microsoft stocks retreated following disappointing reports, while Amazon and Apple bounced back with strong earnings, lifting the indexes again.

Amid this, some investors worry about how AI expansion is being funded. Meta recently announced a $30 billion financing package for its Hyperion data center in Louisiana, utilizing a special purpose vehicle to keep debt off its balance sheet. The company is also reportedly considering an additional $25 billion bond sale, with a prospectus filed with the SEC.

### Final Thoughts

Michael Burry’s warning emerges amid growing debate over whether the AI-driven tech stock surge reflects genuine progress or inflated valuations. His decision to hold a defensive position — effectively sitting on the sidelines — suggests he sees significant risk but no clear opportunity to capitalize on right now.

Investors will be closely watching Burry’s next 13-F filing for clues on whether he maintained this cautious posture through the third quarter of 2025.
https://coincentral.com/big-short-investor-michael-burry-breaks-silence-to-warn-of-market-bubble/

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