Seer, Inc. (SEER) Q3 2025 Earnings Call Transcript

Operator: Good day, and welcome to the Seer Third Quarter 2025 Earnings Conference Call. [Operator Instructions] Please note this event is being recorded. I would now like to turn the conference over to Kelly Gura of Investor Relations. Please go ahead.

Kelly Gura: Thank you. Earlier today, Seer released financial results for the quarter ended September 30, 2025. If you have not received this news release or would like to be added to the company’s distribution list, please send an email to investor@seer.bio.

In addition, during today’s conference call, we will be referencing a slide presentation that can be accessed in the Events and Presentations section of Seer’s Investor Relations website.

Joining me today from Seer are Omid Farokhzad, Chief Executive Officer and Chair of the Board; and David Horn, Chief Financial Officer and President.

Before we begin, I would like to remind you that management will make statements during this call that are forward-looking statements within the meaning of federal securities laws. These statements involve material risks and uncertainties that could cause actual results or events to differ materially from those anticipated.

Additional information regarding these risks and uncertainties appears in the section titled Forward-Looking Statements in the press release Seer issued today. For a more complete description, please see the Risk Factors section of the company’s quarterly report on Form 10-Q for the quarter ended September 30, 2025, and in its other filings with the Securities and Exchange Commission.

Except as required by law, Seer disclaims any intention or obligation to update or revise any financial projections or forward-looking statements, whether as a result of new information, future events, or otherwise.
https://seekingalpha.com/article/4839890-seer-inc-seer-q3-2025-earnings-call-transcript?source=feed_all_articles

Pelosi Won’t Seek Reelection

Former House Speaker Nancy Pelosi is leaving Congress. At 85 years old, Pelosi’s departure marks a significant moment in Democratic politics. The ultra-left, a youth-inspired movement pushing the party further left, is taking a large step toward more progressive policies. Pelosi likely saw the writing on the wall, facing significant challengers in the upcoming election, and chose to make a proactive exit. Her departure may also signal a wave of retirements among the party’s old guard.

WASHINGTON, D.C. — Speculation about Pelosi’s retirement timeline has been rampant for years in San Francisco, a deeply blue and politically active city known for producing national Democratic leaders like Governor Gavin Newsom and former Vice President Kamala Harris. Pelosi had hinted that she would make a major announcement following Tuesday’s election.

Now, the departure of one of the nation’s most recognizable Democrats, who was first elected to Congress in a 1987 special election, signals the end of an era. It also sets off a cascade of campaign maneuvering in San Francisco, as Democrats seize the rare opportunity of an open House seat in this stronghold of Democratic politics.

In Washington, Pelosi’s upcoming exit raises questions about the futures of her senior congressional allies. Pelosi already faced two serious Democratic challengers: Saikat Chakrabarti, a wealthy former tech executive and progressive organizer, and Scott Wiener, a prominent state lawmaker who has been positioning himself to succeed Pelosi for years.
https://theconservativetreehouse.com/blog/2025/11/06/pelosi-wont-seek-reelection/

49ers have a ‘New-Name Defense’ scrambling to fill holes before Rams visit

SANTA CLARA — Three men walked into a bar. Or maybe they wish they did. Kyle Shanahan, Robert Saleh, and John Lynch came together at midfield and gazed at the 49ers’ defensive players they had left for Thursday’s practice, under almost sarcastically sunny skies.

Of course, that unit presses on without Nick Bosa, Fred Warner, and Mykel Williams for the rest of this season. But two more defensive mainstays missed Thursday’s session: linebacker Dee Winters (knee) and defensive tackle Alfred Collins (hip). Also added to the injury report after limited duty were just-acquired defensive end Keion White (groin) and defensive tackle Kalia Davis (ankle).

Alas, more reinforcements could be needed on an ever-changing defense, one that must bond fast Sunday when the 49ers (6-3) host the Los Angeles Rams (6-2). Saleh, in his increasingly challenging encore as defensive coordinator, must orchestrate more magic than ever anticipated from a young and recalibrating defense. Call it a “New-Name Defense.”

So who’s surfacing now as the vocal leader, the enforcer, the turnover-forcing playmaker?

“That’s the exciting part,” Saleh said. “When we were here in ’17 and ’18, it was, ‘Who’s going to be next?’ You saw this little skinny linebacker named Fred Warner and nobody expected it to be him. Jimmie Ward, Jaquiski Tartt, DeForest Buckner and Arik Armstead, all those guys were so young, rose to the occasion, and made a name for themselves.”

That group is gone, except officially for Warner, who was in the 49ers locker room Thursday and in upbeat spirits while scootering around on his surgically repaired right ankle. Still, the 49ers are scouring to fill Warner’s on-field void.

The candidates?

“This group, being as young as it is, I wish I could tell you,” Saleh said. “I have an idea. I’m excited for everybody to take advantage of their opportunity and evolve the way we know they’re capable of.”

Bryce Huff, with a team-high four sacks, is expected to return from a hamstring injury and align on a frontline with last week’s newcomers, White and Clelin Ferrell.

Nametags wouldn’t be a bad idea at this point.

“Man, I’m terrible with names, so just trying to learn everybody’s name is big for me,” White said. “The guys in my room are really cool, real funny. It’s cool to get to know them.”

White gave no indication his groin issue is serious, and he praised Saleh’s “aggressive, one-gap, one-man” scheme. “Coach Saleh says, ‘Go be disruptive, play 100 percent and we’ll figure out the rest after,’” he added.

Ferrell chimed in, saying, “When you come in on a new team, you have, I don’t want to say more important things, but you have so many things you’re trying to learn. It comes with that awkward moment of, ‘What’s your name again?’ But it’s pretty normal.”

Their mission Sunday: keep Matthew Stafford from adding to his NFL lead of 21 touchdown passes.

Lynch, in his ninth season as general manager, defended the 49ers’ trade-deadline motives by pointing to his four earlier trades, from Huff’s arrival in June to White’s acquisition last week. Just because Tuesday’s deadline came without more help didn’t mean the 49ers overslept.

“We weren’t going to get fleeced. We weren’t going to overpay,” Lynch said on KNBR 680-AM. “It’s just not good business.”

And it’s just not a good pass rush or ball-hawking defense that is ushering the 49ers into the second-half push toward the playoffs.

Then again, Saleh’s defense has delivered timely plays, from win-clinching sacks in their first two games at Seattle and New Orleans to last month’s overtime win in Los Angeles, where a fourth-down stop ended things but only after Collins forced and recovered a fumble at the 1-yard line late in regulation.

Linebacker Tatum Bethune, who has a thigh issue ahead of his fourth start in Warner’s place, insists the leadership vacuum is being filled by all.

“We all come together to find out what we can do better together as a defense,” Bethune said. “After the game, we get on the plane, and we all stand up watching film, trying to correct stuff we could have done better in the game.”

**Health Updates**

Quarterback Brock Purdy remains limited in practice for a fourth straight week, and perhaps signaling another week on the sidelines, the 49ers had replacement starter Mac Jones address the media again Thursday. Center Jake Brendel (hamstring) was also limited.

Wide receiver Ricky Pearsall (knee) remained out but ran well on a side field.

Full participants were Jones (knee), wide receiver Jauan Jennings (ankle, shoulder), left guard Ben Bartch (ankle), and cornerback Darrell Luter (Achilles).

The Rams upgraded wide receiver Puca Nacua (chest) and cornerback Darious Williams (shoulder) to full participants while wide receiver Jordan Whittington (back) was their lone player out.

**Extra Points**

Jones said of Christian McCaffrey, the NFL’s 7th-leading receiver: “He’s super talented. I’d seen it from afar, but being on the field with him in OTAs and camp, he’s explosive. He trains all the movements. He gets open and catches the ball, the two vital parts of being a receiver.”

Return specialist Skyy Moore was saddened to learn former Western Michigan teammate and Dallas Cowboys defensive end Marshawn Kneeland died by suicide Thursday following a police chase. Moore said he and Kneeland were part of the same 2019 recruiting class.

Left tackle Trent Williams, a three-time All-Pro and 11-time Pro Bowler, was surprised to learn he won the 49ers’ in-house nod as Offensive Player of the Week.

“When I walked into the O-line room, I got fined for being up there. That’s how I figured it out.”

Why has Williams never been the NFC Offensive Player of the Week?

“That’s a valid point. I’d like to hear the answer, too,” he replied.
https://www.mercurynews.com/2025/11/06/49ers-have-a-new-name-defense-scrambling-to-fill-holes-before-rams-visit/

NexGen Energy Ltd. (NXE:CA) Q3 2025 Earnings Call Transcript

Operator:

Thank you for standing by. This is the conference operator. Welcome to the NexGen Energy Third Quarter 2025 Results Conference Call.

[Operator Instructions]

The conference is being recorded. I would now like to turn the conference over to Mr. Leigh Curyer, Chief Executive Officer and Director with NexGen Energy Limited. Please go ahead, sir.

**Leigh Curyer
Founder, President, CEO & Director**

Thank you, Gaileen. Good morning, and thank you for joining NexGen’s Q3 2025 Financial Results and Investor Conference Call. My name is Leigh Curyer, and I am the Chief Executive Officer of NexGen Energy.

I’m joined today by Travis McPherson, Chief Commercial Officer; and Benjamin Salter, Chief Financial Officer.

During today’s Q3 update, I will provide the latest insights on uranium market dynamics, which are unfolding faster than most industry observers anticipated. This rapid change is driven by an unprecedented global uptake of nuclear energy and the strategic execution of NexGen’s offtake marketing strategy.

Additionally, I will share progress as we prepare for our first of two commission hearings on the federal approval of the Rook I project, scheduled in just 13 days.

We will also provide updates on all Rook I site activities and preparations, as we move forward to execute this generational project that is set to establish new benchmarks in economic, environmental, and social stewardship for the sector.

At the conclusion of this presentation, we will move to the Q&A portion of the call.
https://seekingalpha.com/article/4839862-nexgen-energy-ltd-nxe-ca-q3-2025-earnings-call-transcript?source=feed_all_articles

Rose Abdoo Talks Gilmore Girls 25th Anniversary and Almost Playing Sookie

On October 5, 2000, we were first welcomed into the magical world of Lorelai and Rory Gilmore and Stars Hollow when *Gilmore Girls* premiered on The WB. (Who else remembers the frog?) It hardly feels like it’s been 25 years, and in some ways, it feels like it’s been five minutes. Yet it also feels like it’s been centuries.

To celebrate the 25th anniversary, I’m kicking off a series where I’ll be talking to members of the *Gilmore Girls* cast throughout the next year. First up is the incredible Rose Abdoo, who played town mechanic Gypsy beginning in season 2 and, of course, the iconic additional role of Berta in the 2016 Netflix revival *Gilmore Girls: A Year in the Life*.

We spoke all about her journey with the show as well as her latest role in one of the most popular current shows, *Hacks* on HBO Max (which everybody also needs to watch!). Most surprising to me was learning that Rose originally auditioned for the role of Sookie, which later went to Melissa McCarthy. I think we can all agree that everyone on the show was perfectly cast, bringing us the perfect blend of town chaos and coziness.

We also talked about the recent fan events celebrating the show across the country, and Rose’s experience attending Destination Stars Hollow in Brighton, Michigan. Plus, we shared our excitement to once again attend the Warner Bros. Holidays Made Here event on the show’s set in Burbank, California this December.

Of course, we couldn’t dive into this conversation without discussing her other roles in the Amy Sherman-Palladino universe, including her experience on the legendary and canceled-too-soon ABC Family series *Bunheads* starring Sutton Foster. Rose also filmed a pilot with Amy for a show called *The Damn Thorpes*, a family drama set on a farm that unfortunately did not make it to series.

Tune into our full conversation in the video above. And stay tuned for many more *Gilmore Girls* interviews coming soon!
https://nerdreactor.com/rose-abdoo-talks-gilmore-girls-25th-anniversary-and-almost-playing-sookie/

Microsoft solves 2 Windows problems that plagued it for years

After years of frustration, Windows has quickly addressed two significant issues that have long annoyed users. One problem seemed to be a bug, while the other was maddeningly tedious. However, within a month, Microsoft introduced two key updates to its Windows operating system that finally resolve these issues for users worldwide.

These improvements are just two of many recent enhancements; Microsoft has also upgraded the Start menu, among other features.

### Say Goodbye to a Drained Laptop Battery

Windows appears to have fixed a bug where the “Update and shut down” feature didn’t actually shut down the computer. Instead, it restarted the device, which could lead to a drained battery when users thought their laptops were turned off.

The “Update and shut down” bug was so persistent and widespread that it even became the subject of memes. Thankfully, the madness came to an end late last month with an October 28 update from Microsoft. The update plainly states the fix:

> **Improved:** Addressed underlying issue which can cause “Update and shutdown” to not actually shut down your PC after updating.

This fix means users can now trust that their laptops will fully power down after updates, preventing unexpected battery drain.

### Windows Now Makes It Easy to Add Em Dashes — Writers, Rejoice!

The other fix is great news for writers fond of the em dash (—). In the past, inserting an em dash required the tedious ALT + 0151 keyboard shortcut. For those who regularly switch between a MacBook and a Windows machine, this was a particularly annoying inconsistency.

If your keyboard lacked a numeric keypad, the task was even more difficult. Many users resorted to copying and pasting the em dash from a text file or using imperfect plugins and workarounds.

Now, Windows offers a simple way to insert en dashes and em dashes while typing:

– Press **Windows logo key + Minus (-)** to insert an en dash (–)
– Press **Windows logo key + Shift + Minus (-)** to insert an em dash (—)

Note: If the Magnifier tool is running, pressing Windows logo key + hyphen (-) will zoom out Magnifier instead of inserting an en dash.

### Justice for the Em Dash?

This change could help restore the reputation of the em dash.

With the explosive rise of ChatGPT and other AI writing tools in recent years, one telltale sign that someone might be using a chatbot to generate text was the frequent use of em dashes. Writers abhorred this stereotype because phrases set off by em dashes add rhythm and voice to news articles.

Since ChatGPT is trained on millions of news articles, em dashes naturally appeared often in AI-generated content. This association unfairly gave the em dash a bad reputation, as if their presence in a text was a signal that the writer was cheating.

With Microsoft’s long-overdue update making em dashes easier to use, they may start appearing more frequently in human-written copy. As this punctuation mark becomes more common in everyday writing again, the stigma surrounding it could fade. This change might rightfully restore justice for the em dash.

### Are More Windows Fixes on the Way?

Microsoft officially ended support for Windows 10 last month. Users who have been holding out on switching to Windows 11 might see these updates—and more to come—as a sign that Microsoft is committed to making its operating system more user-friendly.

These improvements aim not only at attracting new users but also at pleasing power users who have been frustrated for years by Windows quirks.

Stay tuned for more updates as Microsoft continues to refine Windows for all users.
https://www.makeuseof.com/windows-em-dash-update-and-shutdown/

Trump implies talks with India continue, praises Modi, says he might visit that country – News India Times

President Trump, during a press conference at the White House, indicated that he may visit India next year. The press conference was held to announce a deal aimed at lowering the price of weight-loss drugs.

During the event, Trump reiterated that applying tariffs on countries was a national security measure and a tool he used to prevent wars. He referred to the recent conflict between India and Pakistan as an example of his success with this approach.

Asked about the Supreme Court’s ongoing hearing on the legality of tariffs imposed by his administration, Trump emphasized that tariffs were akin to a national security initiative. He stated, “I use them for national defense. I ended… say five or six (wars) because of tariffs.”

Trump elaborated on the India-Pakistan conflict, saying, “If you take a look at India and Pakistan, they started to fight. The two nuclear nations were shooting at each other. Eight planes were shot down. There was seven, now it’s eight, because the one that was sort of shot down is now abandoned, and eight planes were shot down.”

He continued, “And I said, listen, if you guys are going to fight, I’m going to put tariffs on you. They both… were not happy about that, and within 24 hours they settled the war. If I didn’t have tariffs, I wouldn’t have been able to settle that war.”

When asked if he was planning to visit India, Trump responded, “Prime Minister largely stopped buying oil from Russia when you plan.” He added, “He’s a friend of mine, and we speak, and he wants me to go there. We’ll figure that out. I’ll go. I had a great trip there with Prime Minister… Modi’s… great man, and I’ll be going.”

Asked if his visit could happen next year, Trump said, “It could be. Yeah.”
https://newsindiatimes.com/trump-implies-talks-with-india-continue-praises-modi-says-he-might-visit-that-country/

Appeals Court Upholds 5-Year Prison Sentence for Brendan Depa in Matanzas Teacher’s Aide Attack

The Fifth District Court of Appeal on Tuesday upheld the five-year prison sentence and 15-year probation term against Brendan Depa, the former Matanzas High School student whose video-captured beating of a teacher’s aide unconscious in February 2023 drew worldwide attention.

A three-judge panel affirmed the decision without an opinion, as is common in appellate decisions. Depa’s lawyer, Hani Demetrious of the Fort Lauderdale-based Robert David Malove law firm, had argued in an appeal last April that Circuit Judge Terence Perkins abused his discretion by sentencing Depa as an adult rather than as a juvenile offender.

Depa was 17 at the time of the attack on Joan Naydich, which occurred after he was disciplined for an electronic game he had—an incident later revealed to have been mishandled by school officials. The State Attorney’s Office charged him with first-degree felony assault of a school employee, trying him as an adult. He faced up to 30 years in prison.

At sentencing, Depa’s defense team urged for a two-year term in a juvenile justice facility to keep him out of state prison and to eliminate the lengthy probation period. However, Judge Perkins was firm on imposing some prison time along with a long supervisory term. Assistant State Attorney Melissa Clark requested seven years in prison and 10 years probation.

Demetrious did not return requests for comment following the appeals court ruling. The decision appears to mark the end of the case, especially as those close to Depa describe him as having accepted responsibility and moved forward.

Gene Lopes, a special education teacher who regularly taught Depa at the Flagler County jail and has kept in contact with him, spoke about Depa in a recent interview.

“He has truly accepted that he did something horrible and that there were consequences for that,” Lopes said. “He’s a good human, he made a horrible mistake, and more than ever he realizes that, but his soul is good. His strong beliefs—strong Christian beliefs—have also allowed him to see other points of view, and that amazes me.”

Lopes disagreed with both the appeals court decision and Judge Perkins’s original sentence. Despite this, he sees Depa as preparing for life after prison. He talks with Depa every other week and last visited him three weeks ago at Wakulla prison in Florida’s Big Bend, where Depa gave him “a big Brendan hug.” The Department of Corrections describes Wakulla as “a faith and character based facility.”

Depa, now 20 years old, has maintained a very positive attitude, Lopes said. “When I saw him he was upbeat, content, and had a much better understanding of what the consequences could have been. I think the time has helped him really reflect on his actions, and he’s been a model inmate.”

While incarcerated, Depa has engaged in reading and writing, and has participated in several faith-based programs. He has attended Jewish services, studied the Bible extensively, and explored Muslim studies out of curiosity. He has also passed his full GED and hopes to attend college after his release, aiming for a career in counseling to help others in similar circumstances.

Lopes expressed his view that Depa has done much of the work needed for self-improvement. “I don’t know what more time in prison will do for him. Whatever he needed to fix, I think he has a solid grasp on it. His biggest challenge now is his intellectual curiosity and the limits prison places on satisfying it.”

By sentencing, Depa had already served a year and a half in juvenile detention in Jacksonville and at the Flagler County jail after turning 18. His scheduled release date is August 3, 2027. With potential gain time or early release for good behavior—which does not count time served in county jails—he could be freed after serving approximately 85 percent of his sentence, possibly as early as February 2027.

His most recent prison photo shows a clean-shaven young man, with a thin mustache and wearing brown horn-rimmed glasses instead of black. Unlike typical inmate mugshots, Depa appears relaxed, with a faint, almost Mona Lisa-like smile.

The attack on Joan Naydich had included profanities and racist slurs, for which Depa has accepted full responsibility. “He understands it could have been much worse for Joan,” Lopes said. He also recognizes the disparity in sentencing between himself and others convicted of similar offenses but of different races.

Depa is aware, for example, of a case involving the white son of a Flagler County Sheriff’s deputy who received a five-year prison sentence followed by five years probation for a hit-and-run death of a Black woman. Although the cases had different judges, Depa sees this as an example of sentencing disparity.

“He’s aware of all that but it doesn’t control him,” Lopes said. “He focuses on preparing himself for life outside the prison.”

Depa does not bear resentment, nor does he idly count down the days until his release. Instead, he spends his time constructively. He has not been the target of violence and reports being treated well, with only one minor incident noted.

He has changed his appearance, now working out regularly—something he never did before—indicating that his more relaxed prison photo reflects a sustained personal change.

Lopes is one of several people, including family members, who visit and maintain contact with Depa despite the prison’s isolated location. Depa’s mother lives in the Tampa Bay area.

“He’s very optimistic about the future. Myself, his mom, we’re all hopeful he’ll get through this,” Lopes said. “When he comes out, he’ll find some niche where he can be successful.”

Lopes also noted that, despite some of the negative publicity, many people have come to know a different side of Depa—one that is now his predominant side. This change may open doors for him once he is released.

When asked about the support network that has helped Depa through prison, Lopes gave a surprising answer.

“He’s been a lifeline to me. In all honesty, he’s been a lifeline,” Lopes said. Depa has inspired him to return to teaching, which he now does in St. Johns County. “He’s changed my life.”
https://flaglerlive.com/depa-appeal-fails/

Lotus House unveils The Children’s Village to provide crucial services for kids in Overtown

MIAMI (WSVN) – Lotus House has unveiled The Children’s Village, a new facility designed to provide several vital resources for children and families in Miami’s Overtown neighborhood.

Located on Northeast 14th Terrace, directly across from Lotus House’s 500-bed shelter, The Children’s Village is home to a preschool, after-school care programs, intervention services, and healthcare support. This vibrant center brings together multiple local youth organizations under one roof, united in their mission to support kids and families in the community.

“During the pandemic, we realized that our kids needed more than what we were offering them, so we came up with the idea of building a playground. Shortly after, we realized that they needed more than that. So we invited all of the providers who offer amazing services in Overtown to join us in one roof,” said Lotus House Executive Director Isabella Dell’Oca.

Among the programs offered at The Children’s Village is Girl Power Rocks, which focuses on empowering young girls through educational support, confidence-building, and safety awareness.

“We provide them with different skills to avoid dangers. For instance, trafficking is a significant concern here in Miami, so we address these issues with the girls and provide them with tools like conflict resolution and guidance on how to be better citizens in the community,” explained Rashada Campbell, Director of Operations for Girl Power Rocks.

The Children’s Village is open and available to any youth residing in Overtown, aiming to create a safe and supportive environment for the neighborhood’s children and families.
https://wsvn.com/news/local/miami-dade/lotus-house-unveils-the-childrens-village-to-provide-crucial-services-for-kids-in-overtown/

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